A Primer on Thrombotic Thrombocytepenic Purpura – TTP

A Primer on TTP

Thrombotic thrombocytopenic purpora (TTP), abreviated to TTP or alternatively called Moschcowitz syndrome, is a rare blood disorder that causes a number of microscopic blood clots to form in small blood vessels throughout the body.

The disease is caused by the spontaneous pooling of platelets that coagulate in the small blood vessels. There are two different forms of TTP: idiopathic and secondary. The idiopathic form is connected to the fact that affected patients don’t produce enough of the ADAMTS13 enzyme that is responsible for linking platelets, blood clots and the blood vessel wall during blood coagulation, or the process by which blood clots naturally.

Secondary TTP occurs when a patient exhibits typical TTP symptoms that are accompanied by a number of specific medical conditions, including cancer, bone marrow transplantation due to bone marrow damage, pregnancy, use of platelet aggregation inhibitors or immunosuppressants, as well as an HIV infection.

Amongst Plavix side effects, the drug has been linked to thrombotic thrombocytepenic purpura (TTP), which occurs in about one to three out of every 1 million people.  thrombotic thrombocytepenic purpura (TTP) is a serious condition that results in death in 10 to 20 percent of patients. Since the early 1990s, the standard treatment for TTP has involved removing a patient’s blood plasma and replacing it with donor plasma. The treatment is required daily for a period of one to eight weeks, at which point patients’ bodies will cease to consume platelets and begin to see normal hemoglobin levels.

Additional Plavix side effects include the very conditions that Plavix is often prescribed to ward against.  Other side effects of the blood thinner include: heart attack, strokes, internal hemorraging, cerebral bleeding, bone marrow damage, gastrointestinal bleeding, and bleeding ulcers.

A number of Plavix lawsuits have been filed claiming Plavix makers Sanofi-Aventis and Bristol-Myers Squibb have not adequately warned users of Plavix side effects such as TTP. The Plavix lawsuit also claims that while the number of Plavix patients who develop TTP Plavix side effects is small, it’s possible to contract thrombotic thrombocytepenic purpura (TTP) even if a patient takes the drug for a very short period of time.

The symptoms that accompany TTP can be easily confused with those of a stroke, such as headaches, confusion, malaise, fever, paralysis or difficulty speaking.  They can potentially be extremely serious if ignored, perhaps being signs of something more serious, such as cerebral bleeding, or internal hemorraging.  Anyone exhibiting these symptoms should contact a doctor immediate for observation and blood tests. With proper treatment, more than 80 percent of TTP patients survive following an extensive round of plasma transplants.

Source: Wikipedia.org