The CYP2C19 gene variant may be slow metabolizers of the anti-blood clotting drug, Plavix, which may make it less effective for them. This is yet another Plavix side effect adding to a host of other Plavix side effects.
“According to OregonLive.com, the CYP2C19 gene variant is more common in people of Asian descent. But it does affect other ethnicities as well, including fewer than 5 percent of Caucasians and African-Americans. But simply carrying the gene variant isn’t a good predictor that an individual will not be able to metabolize a drug. One study of Han Chinese – an ethnic group in which the gene variant affects roughly 40 percent of the population – only 20 percent turned out to be slow metabolizers.”
The U.S. Food & Drug Administration (FDA) has ordered that Plavix have the warning placed on the box stating that people who have reduced function of their CYP2C19 liver enzyme can’t convert Plavix effectively into its active form. This means these slow metabolizers may not receive the full benefits of Plavix and may still remain at risk for heart attack, stroke and cardiovascular death. Previously, the FDA had a warning on the Plavix label telling people with the CYP2C19 variant that they may have trouble converting Plavix to its active form, making it less effective.
According the FDA, it’s estimated that 2 percent to 14 percent of the U.S. have the CYP2C19 variant, making them poor metabolizers.
It is up to doctors to determine if the patient should get an alternative dose of Plavix, or change the patient to other anti-platelet medications. DNA tests are available to determine if a patient has the CYP2C19 variant, making them poor metabolizers.
“According to the DNA testing firm Genelex, CYP2C19 acts on 5-10 percent of drugs in current clinical use. Genetic testing can look for common changes CYP2C19 gene to determine if an individual may have difficulty metabolizing a drug. While this may help doctors choose the best drug and dose for an individual with less trial and error, it’s not clear how worthwhile such testing is. What studies have been done on this type of testing have failed to find a clear benefit.”
Plavix is also associated with a number of side effects including gastrointestinal bleeding and cerebral hemorrhaging, eye bleeding, musculoskeletal bleeding, respiratory tract bleeding and skin bleeding. Other Plavix side effects are Thrombotic Thrombocytopenic Purpura or TTP, a rare blood condition that causes blood clots to form throughout the body and hypotension if combined with antibiotics.
If you or a loved one suffered a Plavix side effect including a heart attack, stroke, gastrointestinal bleeding or TTP , you may have valuable legal rights. To discuss your case with one of our Plavix side effect lawyers, please fill out our online form, or call 1 800 LAW INFO (1-80-529-4636) today.